Biochem/physiol Actions

Primary TargetDNA methyltransferase inhibitor

General description

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).

A cytosine analog that acts as a DNA methyltransferase inhibitor. Shown to restore mRNA and protein expression of caspase-8 and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) sensitivity of resistant cell lines. Also reported to enhance apoptosis induced by histone deacetylase (HDAC) inhibitors.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Eggert, A., et al. 2001. Cancer Res.61, 1314.Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.Zhu, W.G., et al. 2001. Cancer Res.61, 1327.Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.Haaf, T. 1995. Pharmacol. Ther.65, 19.Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Preparation Note

warming is required to achieve complete solubilization

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)